CLINICAL INFORMATION :

16 month-old girl. HBV serology +. Clinic in favour of chronic hepatitis.

HISTOLOGY :

• 4 portal triads à classification limited
• Viral B chronic hepatitis 
  Mild activity (Fig. 1 : focal " piece meal necrosis ")
  Portal and septal fibrosis 
  Metavir A1 F2à3
• HbsAg : membranous, ++ (Fig. 2)
  HbcAg : nuclear +++ (> 60 % hepatocytes) (Fig. 3)

==> " Generalized HBcore type "
  

fig. 1		fig. 2
fig. 3