CLINICAL INFORMATION :

59 year-old woman. Transvenous liver biopsy. Cholestasis. Normal pressure. PBC ?

HISTOLOGY :

• Steatosis
• On serial slides : typical bile duct lesion (Fig. 38) :
  -    interruption of the basal membrane of the bile duct
  -    anisonucleosis of the epithelium
  -    epithelial vacuolisation
  -    intraepithelial lymphocytic infiltration
  -    peripheral lymphocytic infiltrate

==> Primary biliary cirrhosis (stade 1)

fig. 38