CLINICAL INFORMATION :

• 47 year-old woman
• Increased ALT and Gammaglobulines, FAN+
• Jaundice.
• AUGMENTIN* 6 months ago ==> hepatitis
• ==> ? Autoimmune hepatitis favoured by AUGMENTIN* ?

HISTOLOGY :

• Contributivity OK
• Preserved lobular pattern with extensive portal fibrosis and formation of porto-portal bridging.
• Severe " piece meal necrosis " + centrilobular collapsus
• Many plasmatocytes in inflammatory infiltrate
• Macrophages containing PAS + diastase resistant pigments ==> sign of previous necrosis
• Autoimmune hepatitis - severe activity - Severe portal fibrosis with porto-potal bridging
  Metavir : A3 F3

fig. 22		fig. 23
fig. 24		fig. 25